منابع مشابه
Iron restriction
Iron restriction is the body’s removal of freely available iron from blood and extracellular fluid, as part of the systemic inflammatory response [1]. This process is mediated by hepcidin, which ‘locks’ iron into somatic cells by down-regulating the iron exporter protein ferroportin [2]. Iron accumulates within macrophages, hepatocytes and gut enterocytes, but cannot enter the circulation [1, 2...
متن کاملIsocitrate ameliorates anemia by suppressing the erythroid iron restriction response.
The unique sensitivity of early red cell progenitors to iron deprivation, known as the erythroid iron restriction response, serves as a basis for human anemias globally. This response impairs erythropoietin-driven erythropoiesis and underlies erythropoietic repression in iron deficiency anemia. Mechanistically, the erythroid iron restriction response results from inactivation of aconitase enzym...
متن کاملProtein Expressions and Their Immunogenicity from Riemerella anatipestifer Cultured in Iron Restriction Medium
Riemerella anatipestifer was cultured in both iron restriction media and normal media. Two-dimensional gel electrophoresis identified 23 proteins that significantly increased in the iron restriction media. Of them 12 proteins were analyzed with mass spectrography. Nine of 12 proteins belong to 6 different protein families: fibronectin type iii domain protein, secreted subtilase family protein, ...
متن کاملIncreased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease.
The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment suggests a potential restriction of HIV-1 infection in SCD. We investigated HIV-1 ex vivo infection of SCD peripheral blood mononuclear cells (PBMCs) and found that HIV-1 replication was inhibited at the lev...
متن کاملDietary iron restriction inhibits progression of diabetic nephropathy in db/db mice.
Excess iron causes oxidative stress through hydroxyl-radical production via Fenton/Haber-Weiss reactions. Recently, body iron reduction has been found to ameliorate diabetes. In the present study, we examined the protective effect of dietary iron restriction against diabetic nephropathy in the db/db mouse model of diabetic nephropathy using db/m mice as controls. The db/db mice were divided int...
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ژورنال
عنوان ژورنال: Evolution, Medicine, and Public Health
سال: 2015
ISSN: 2050-6201
DOI: 10.1093/emph/eov011